Obagi Tretinoin 0.025% Cream

Acne treatment cream
Topical treatment for acne vulgaris. Available by prescription only, all Obagi tretinoin formulations are non-comedogenic and fragrance free.

Prescription required. Contact your healthcare provider to purchase, or find a nearby physician who offers this product.
Call for Price
Earn 106 Premier Points
Tretinoin is the generic name for synthetic, first-generation all-trans-retinoic acid. Topical tretinoin first arrived on the dermatology scene in the 1960s. It is a prescription drug approved to treat acne, and in a few other FDA-approved products, to treat fine facial wrinkling, limited psoriasis, and other conditions.

Available in multiple strengths and formulations by prescription only, Obagi tretinoin creams and gel work deep inside the skin to treat acne.
Each gram contains:
Tretinoin 0.025%, stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water

Katherine Knicely

1 months ago

Not super excited about this product. Did not see a great difference in my skin

Autumn Barnes

1 months ago

I absoutly love this product!!

Addie DePoy

2 months ago

A game changer for my skin

Alicia Vann

2 months ago

Amazing product!

Jessica Heimann

4 months ago

I've started daily use on my neck and decolletage as that area was starting to show signs of aging. In just a few weeks I have already noticed improvement.

Sarah Stephenson

5 months ago

While I like the Tretinoin cream and had good results I found it to be slightly drying. I prefer the Tretinoin gel from Obagi.

Courtney Kelley

6 months ago

Along with the face wash and moisturizer I have seen a huge improvement in my skin.

Amber McQuoid

7 months ago

This is the powerhouse of skin care products. I did not have any issues transitioning from retinol, but got all of the intended benefits from it. I have since used this entire tube and upgraded to the 0.05% and love how everything transitions so smoothly together.

Cynthia Andert

1 years ago

Very subtle change every month. I continue to see real improvement and I am thrilled!

Ashley Smith

1 years ago

Good entry level cream for beginners

Tina Hicks

1 years ago

I was suffering from a small amount of acne, which was frustrating, as I never did in my youthful years. However, this cleared it up right away, no issues since.

Marcia McDermott

1 years ago

It took a few weeks for my skin to adjust - I had to use the sandwich method, Obagi hydrate, trent, and hydrate again to get thru the dry phase. I will never use another retonid cream.

Melissa Thompkins

1 years ago

Excellent results

Heidi Perez

1 years ago

This was my first tret ive used and it was so gentle. The perfect segue into the .05 gel for winter '

Tina Wagner

1 years ago

Great combo to reduce wrinkles and even out the skin!

Kimberly Falkenstein

1 years ago

My skin complection and texture are much improved after 1 week.

Pamela Munyak

1 years ago

Love this product

Kathleen Falco

1 years ago

Excellent!

Sally Taylor

1 years ago

The only one i trust

Rima chehab

1 years ago

I skin loves this

Kriste Brug

1 years ago

Great stuff it has smoothed my skin amazingly

Casey Zier

1 years ago

Love

Josey Whorley

1 years ago

My favorite products

Amber Flory

2 years ago

Just started using, a little goes a long way.

Chessney Miller

2 years ago

Great product! I use a small amount mixed with Obagi moisturizer at night and my skin has never felt or looked better!

Rhonda Vanover

2 years ago

Amazing

Deanna Sholas

2 years ago

After purchasing I noticed this product is also avaliable in 0.05% as a gel. I will try next because I already like this one.

Megan Morrow

2 years ago

I love this product!! 10/10 recommend!

Danielle Capogna

2 years ago

Perfect for my daughter

Mariah Vasquez

2 years ago

great to start and work up to a stronger tret

Nicole Sisk

2 years ago

A necessary product for keeping your skin smooth and useful.

Morgan Butler

2 years ago

Has really helped improve fine lines

Cheryl Blair

2 years ago

Love with the blender

Heather Goodenow

3 years ago

Mu absolute favorite product!!

Donna Caudle

3 years ago

This is the absolute best stuff ever!! Cleared my adult acne and helping shrink my pores and control oil

Britnee Palshan

3 years ago

❤️❤️❤️

Patricia Campola

3 years ago

Excellent product!! My skin looks amazing.

Carrie Coleman

3 years ago

Works great!!! My skin has really started looking better.

Karla Mancilla

3 years ago

Gentle but soooo effective!!!

Gloria Buccino

3 years ago

Thumbs up for this cream, would purchase again

Dawn Olinger

3 years ago

A little bumpy to start as it brings all blemishes to the surface but give it a couple weeks and skin is blemish free

Ashley Reeves

3 years ago

I think this product is affective. It feels like a hydrocortisone cream and takes a second to fully rub into the skin. I can feel it on my skin but it doesn’t feel greasy. I am excited to see how it works after six months.

Megan Culbreth

4 years ago

Obagi Tretinoin is a must have product!

Need to Know

IMPORTANT SAFETY INFORMATION

Tretinoin Cream Indication: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: or Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.

IMPORTANT SAFETY INFORMATION

Tretinoin Cream Indication: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: or Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.

Precautions: Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin Cream and Gel, and patients with sunburn should be advised not to use the product until fully recovered.

Patients who have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided.

Weather extremes, such as wind or cold, also may be irritating to patients using tretinoin.

Tretinoin Cream and Gel should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Topical use may induce severe local erythema and peeling at the site of application. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, discontinue use temporarily, or discontinue use altogether.

Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition.

Pregnancy Tretinoin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Adverse Reactions The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, treatment should be discontinued or adjusted to a level the patient can tolerate.

To report SUSPECTED ADVERSE REACTIONS contact FDA at fda.gov/medwatch or call 1-800-FDA-1088.

IMPORTANT SAFETY INFORMATION

Tretinoin Cream Indication: Tretinoin Cream is indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: or Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.

How to Use

Morning Routine:

  • Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne.

Nighttime Routine:

  • Wash with a mild soap and dry skin gently
  • Wait 20 to 30 minutes to allow skin to completely dry
  • Squeeze no more than half an inch of medication onto fingertip; more medication will not yield faster or better results and may cause irritation
  • Apply onto face, covering affected area lightly, starting with your forehead, chin, and both cheeks, then spread over the entire affected area
  • Avoid corners of the nose, mouth, eyes, and open wounds
  • Tretinoin is for topical use, only.
  • Tretinoin should be applied once daily, or as directed by physician.
  • Please ensure to always read and follow the Patient Instruction in the Prescribing Information leaflet that accompanies your tretinoin prescription.
  • Tretinoin acne treatment should be kept away from the eyes, the mouth, paranasal creases, and mucous membranes.
  • Application of excessive amounts of gel will not provide incremental efficacy.
  • Store tretinoin cream at controlled room temperature below 80°F

Morning Routine:

  • Apply a moisturizer, preferably with sunscreen, that will not aggravate your acne.

Nighttime Routine:

  • Wash with a mild soap and dry skin gently
  • Wait 20 to 30 minutes to allow skin to completely dry
  • Squeeze no more than half an inch of medication onto fingertip; more medication will not yield faster or better results and may cause irritation
  • Apply onto face, covering affected area lightly, starting with your forehead, chin, and both cheeks, then spread over the entire affected area
  • Avoid corners of the nose, mouth, eyes, and open wounds
  • Tretinoin is for topical use, only.
  • Tretinoin should be applied once daily, or as directed by physician.
  • Please ensure to always read and follow the Patient Instruction in the Prescribing Information leaflet that accompanies your tretinoin prescription.
  • Tretinoin acne treatment should be kept away from the eyes, the mouth, paranasal creases, and mucous membranes.
  • Application of excessive amounts of gel will not provide incremental efficacy.
  • Store tretinoin cream at controlled room temperature below 80°F

FAQs